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**Rare Blood Disorders**: In extremely rare cases, high doses of glutathione may lead to blood disorders such as hemolysis, especially in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency

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In relation to the present review, CHOP and asparagine synthetase are over-expressed when cells are deprived of a particular amino acid, for instance leucine, lysine, phenylalanine and methionine ( Reference Jousse, Bruhat and Ferrara 63 , Reference Bruhat, Jousse and Wang 64 )