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aureus (MRSA) infection, mitoROS were generated and delivered directly to the phagosome by mitochondrial-derived vesicles (MDVs) in a Toll-like receptor signaling-dependent manner (Warnatsch et al., 2017), mitoROS can also modulate the antimicrobial functions of innate immune cells by regulating production of multiple cytokines both in vitro and in vivo ( Bacterial Response to Oxidative Stress: Antioxidant and Metabolic Defenses The systems in bacteria that regulate the expression of antioxidant defense networks have been extensively reviewed (Reniere, 2018)