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Recent efforts have focused on the use of drugs already approved by the Food and Drug Administration (FDA) for other diseases that have also shown efficacy in delaying cystogenesis, including pioglitazone, sirolimus, and metformin (Table 1) [9–12]

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Beyond passive diffusion and transcellular transport, these transporters can be broken down into five additional categories: active efflux transport, carrier-mediated transport, receptor-mediated transport, absorptive-mediated transport, and ion transporters (Fig