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Washout periods: for crossover designs, a 7-14 day washout should be adequate given both short serum half-life and the typical decay timeline of tissue-level effects post-dosing

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Similarly, some commonly occurring plant phenolics are efficiently metabolized by the gut flora of rodents to phenol, catechol and other simple phenols.8283 Escherichia coli can convert glucose to catechol through a minor metabolic pathway;84 however, the amount of catechol that might be generated by gut flora from sugars is unknown