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In deeply anaesthetised rats (placed in ventral position) the tail was transected with a surgical scalpel 3 cm from the tip (and submerged into a tube with 15 ml of saline at room temperature in vertical position) and the duration and amount of bleeding were measured to evaluate the hemostatic effect of the agents or saline administration

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Complete disappearance or significant improvement of withdrawal symptoms was confirmed by 97% of alcohol-addicted patients and 87% of opiate-addicted patients in clinical study of 107 patients treated via DSIP

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