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Similarly, RDP58, a peptide-based anti-inflammatory agent, improved colitis in mice by enhancing microbial diversity and promoting short-chain fatty acid (SCFA)-producing bacteria, which in turn stimulated regulatory T cell (Treg) differentiation—a critical anti-inflammatory mechanism

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Studies show that the relapse rate is nearly 60% within two years, and up to 40% after two years, meaning that vitiligo tends to relapse after treatment and is difficult to cure, presenting a major clinical challenge that needs to be addressed (Oh et al., 2021