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Key Takeaways Intramuscular (IM) glutathione injections deliver 200-600 mg per dose into muscle tissue with peak blood levels at 30-45 minutes, while intravenous (IV) administration delivers 600-2,000 mg directly into circulation with immediate bioavailability Published pharmacokinetic data shows IV glutathione produces 3-4 times higher peak plasma concentrations than equivalent IM doses, but IM injections maintain therapeutic levels 40-60% longer due to depot effect IM administration carries lower infection risk (0.1% versus 2-3% for IV), requires no specialized equipment, and costs $25-75 per session versus $150-400 for IV infusions Neither route has FDA approval for cosmetic skin lightening, the most common off-label use, and both carry identical contraindications for patients with asthma or sulfite sensitivity The short answer Intramuscular glutathione injections deliver the antioxidant into muscle tissue (typically deltoid or gluteal), while intravenous administration infuses it directly into the bloodstream