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They found that DDD therapeutically targets AS by enhancing mitochondrial function through the HIF-1 signaling pathway, reducing ROS levels, and modulating GPX4, Bcl2, and Bax protein levels, thereby benefiting AS and hyperlipidemia (Wu et al., 2023a)

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Novo Nordisk developed CagriSema as a fixed-combination product with a single injection device, though the Phase 3 REDEFINE trials used co-administered separate injections