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72 For bacterial peptidoglycan sensing, NOD1 and NOD2 signal through RIPK2, which couples receptor oligomerization to ubiquitin-dependent scaffolding that sustains NF-κB and MAPK activation

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Thus, most perioperative NAC studies have investigated outcomes related to inflammation and oxidative stress by assessing postoperative complications ranging from global surgical outcomes, including mortality, to organ-specific outcomes involving the kidneys, heart, liver and lungs (Table 1)