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And I think we now appreciate that it's doing a lot of different things in a lot of different brain structures, not unlike dopamine, but perhaps even more so because you see evidence out there for serotonin and resilience, but also serotonin and pair bonding

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NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRI’s Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI